Blueprint for Safety: The Handbook That Defined Supplement Science

How do we know how much of a vitamin or mineral is safe to take? In this episode of Supplement Source, we explore the history and impact of the Vitamin and Mineral Safety Handbook, the go-to playbook that has shaped supplement regulations and formulations for decades. Jeff Ventura sits down with Andrea Wong (CRN) and Andrew Shao (Chromadex) to discuss how this handbook became a scientific cornerstone, the fight against overly conservative regulations, and why updating it is more crucial than ever. Tune in for an inside look at the science, strategy, and ongoing effort to protect responsible innovation in the supplement industry!

About the Council for Responsible Nutrition (CRN) 
The Council for Responsible Nutrition (CRN), founded in 1973 and based in Washington, D.C., is the leading trade association representing the dietary supplement and functional food industry. Bringing together manufacturers, ingredient suppliers, and service providers, CRN unites its member companies around a shared commitment to science, transparency, and responsible business practices—advancing a strong, credible marketplace that supports consumer health and industry growth.

In an increasingly complex regulatory and media environment, CRN serves as the industry’s front line—shaping science-based policy, defending market access, and countering misinformation. Through strategic advocacy, self-regulatory leadership, voluntary guidelines, and evidence-based communications, CRN ensures that responsible companies are recognized, protected, and positioned to innovate and compete. Learn more at crnusa.org and follow @CRN_Supplements on X and LinkedIn.